By origin he was Greek. Finished Serbian elementary school in Cerevic and German in Petrovaradin. Five grades of grammar school he finished in Novi Sad. The final three grades he went to Szeged and Pressburg, Bratislava (1864-67), under surname Grcic. In Vienna, he studied medicine as a scholar of the Serbian Cultural Society (1867-74). Name Milenko he added himself by the name of the girl that waqs his only truly love. Because of tuberculosis, he interrupted his studies, and returned to his mother, who had settled him in the forest silence of Beocin monastery where he died. He was buried next to the monastery church with rhymes of J J Zmaj on the memorial verses "Mountain keeps your body, and a Serbhood your memory". His residual manuscripts were burned during the war in 1914. Some of the backlog of manuscripts were found and kept in Cerevic museum. Street where he was born, todays main street, is now called by his name. In his hometown of Cerevic there is also a museum with his name.
Улица у којој је рођен Јован Грчић Миленко, иначе главна улица, се сада зове његовим именом. У његовом родном месту Черевићу такође постоји и музеј са његовим именом.